Secreted Frizzled-Related Protein 5 is Associated with Glucose and Lipid Metabolism Related Metabolic Syndrome Components Among Adolescents in Northeastern China
نویسندگان
چکیده
منابع مشابه
Inhibition of secreted frizzled-related protein 5 improves glucose metabolism.
Elucidating the role of secreted frizzled-related protein 5 (SFRP5) in metabolism and obesity has been complicated by contradictory findings when knockout mice were used to determine metabolic phenotypes. By overexpressing SFRP5 in obese, prediabetic mice we consistently observed elevated hyperglycemia and glucose intolerance, supporting SFRP5 as a negative regulator of glucose metabolism. Acco...
متن کاملLoss of Secreted Frizzled-Related Protein-1 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma.
AIMS Secreted Frizzled-Related Protein-1 (SFRP1) is a well-known negative regulator of the wingless type (Wnt)-β-catenin pathway and its inactivation plays an important role in the development and progression of many cancers. In this study, we aimed to determine the clinical significance of SFRP1 expression in intrahepatic cholangiocarcinoma (IHCC) and to define the relationship to Wnt-β-cateni...
متن کاملEpigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis.
Disruption of the Wnt pathway is thought to be crucial in the development of human cancer. Pathway inhibitory members of the secreted frizzled-related protein (SFRP) family were found to be downregulated due to epigenetic inactivation in various malignancies. To date, only SFRP1 has been studied in human breast cancer and we questioned whether other SFRP genes may be implicated in the pathogene...
متن کاملSecreted frizzled related proteins: Implications in cancers.
The Wnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumor progression becaluse of its effect on cell proliferation, migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or to Frizzled receptors. In recent years, aberrant ...
متن کاملimmunohistochemical analysis and role of secreted frizzled-related protein-4 in polycystic ovary-induced rat
objective: the role of wnt signaling and its antagonist; secreted frizzled related protein type 4 (sfpr4) was reported in rodent ovarian follicular development. this study examines immunolocalization of sfrp4 in ovaries of polycystic ovary (pco) rat model and evaluates its role in follicular growth arrest and its premature differentiation. materials and mathods: pco was induced with daily admin...
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ژورنال
عنوان ژورنال: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
سال: 2021
ISSN: 1178-7007
DOI: 10.2147/dmso.s301090